Ceftizoxime

Medicine name: ceftizoxime

Drug category: Third-generation cephalosporin antibiotic

Indications:

Infections of the lower respiratory tract

• Urinary tract infections

• Gonorrhea infection

Abdominal and uterine visceral infections

• Septic

• Meningitis

• Skin and bone infections

Mechanism of action:

By inhibiting the synthesis of the bacterial cell wall, this drug causes osmotic instability of bacteria and has a bactericidal effect.

Pharmacokinetics:

After absorption, this drug is excreted by the kidneys and in case of renal failure, the dose should be adjusted.

The correct amount and method of consumption:

The exact dose and method of administration of this drug should be determined according to the patient's condition, severity of infection and susceptibility of microorganisms to this antibiotic, but the usual dose of the drug is as follows.

adults:

The usual dose is 1 to 2 grams intramuscularly or intravenously every 8 to 12 hours, depending on the type of disease.

• In gonorrhea infection: 1 gram of the drug intramuscularly and in a single dose.

In abdominal and uterine infections: 2 g of the drug every 8 hours intravenously.

• In urinary tract infections: 500 mg intravenously or intramuscularly every 12 hours.

In bacterial septic infection: 6 to 12 grams daily intravenously. The dose may be reduced if the patient's condition improves.

children:

The usual dose for children 6 months and older is 50 mg per kg of body weight every 6 to 8 hours and the maximum daily dose is increased to 200 mg per kg of body weight.

Direct intravenous injection: Dissolve the contents of 500 mg vials in 5 ml and 1 g in 10 ml of injectable distilled water and gently inject the resulting solution over a period of 3 to 5 minutes.

Intramuscular injection: Dissolve the contents of 500 mg vials in 1.5 ml and 1 g vials in 3 ml of injectable distilled water and inject deeply.

Intravenous infusion: Dissolve the contents of 500 mg vials in 5 ml and 1 g vials in 10 ml of injectable distilled water and re-dilute the resulting solutions with 50 to 100 ml of infusion fluid such as injectable sodium chloride. Dilute 5 to 10% injectable dextrose, 5% dextrose solution, 0.9% injectable sodium chloride, injectable lactate ringer solution, injectable ringer solution, 10% modified sugar solution in distilled water and 5% injectable sodium bicarbonate solution and administer according to the prescribed dose. Infuse.

Contraindication:

If you are allergic to this drug, do not prescribe it.

Warning:

• In case of allergic reactions, stop injecting the drug and consult a physician immediately.

Do not mix Ceftizoxime with aminoglycosides for intravenous injection.

If intramuscular injection of ceftizoxime with aminoglycosides such as gentamicin is required, these drugs should be injected at two separate points.

In diabetics, injections of cephalosporins can cause a false positive reaction to the urine glucose test or falsely show a higher than real glucose level. In this case, consult your doctor or pharmacist.

In people with kidney failure, the dose should be adjusted by a doctor.

• The solution ready for injection is light yellow to yellow, do not inject if the color changes.

Solutions prepared for intramuscular injection and direct intravenous injection can be stored for 24 hours at room temperature and 96 hours at refrigerator temperature, but it is recommended to use freshly prepared solutions.

Drug interactions:

If you are taking other medicines and supplements with this medicine, consult your doctor or pharmacist.

Side effects:

Each drug may cause side effects in parallel with the desired therapeutic effects, although not all side effects are seen in one person, but if any of the following side effects occur, consult your doctor or pharmacist.

Local side effects at the injection site, itching, skin rash and burning

Pregnancy and lactation:

This drug is in group B during pregnancy and the benefits and harms of prescribing it during pregnancy and lactation should be evaluated by a doctor.

Storage:

Store the dry product at a temperature below 30 ° C and away from light.

Keep the medicine out of the reach of children.

Product shape and packaging:

Vials containing ceftizoxime 500 mg and 1 g are supplied in 20-digit boxes.

Manufacturer:

Daana Pharma Co.